Day

October 27, 2017

Characterizing the Thermal and Chemical Stability of a mAb

In these experiments, ARGEN was used to characterize the thermal and chemical stability of a monoclonal antibody and subsequently establish quantitative and qualitative properties such as pH and temperature dependence on aggregation kinetics. Additionally, SEC elution profiles were superimposed onto Mw/Mo output, providing a robust comparison and identification of the stability landscape for the mAb....
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Biopolymer Characterization & Polymer Degradation

Understanding the thermal, chemical and mechanical stability and physical properties of polymers is essential for development success. The case studies below outline the experimental methodologies and data analysis using ARGEN™ to monitor polymer degradation and to characterize molecular weight as well as the effects of temperature, shear stress and solution conditions on the stability of...
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Real-time Analytics during PVP Polymerization

ACOMP was used to monitor the free radical polymerization of vinyl pyrrolidone using UV Absorption (UV), capillary viscometry and multi-angle light scattering (MALS). This technical note describes how ACOMP is used to monitor the polymerization of vinyl pyrrolidone under small changes in initiator concentrations.
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