Category

Technical Notes

Assessing Stirring Stress and Other Impacts of Bioprocessing

The successful development of biotherapeutics requires an in-depth understanding of the impacts associated with mechanical and physical stress. Instability and subsequent aggregation can render them biologically inactive or even induce an immunological response in patients. Stirring stress is one of the most notable factors which disrupts native biopolymer structure and promotes aggregation. However, contact stirring...
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Using 90° Static Light Scattering to Determine Mw

On the limits of 90° static light scattering for determining weight average molar mass Mw   A discussion with Chief Science Officer, Dr. Wayne Reed   This Technical Note assesses the fractional error in Mw that results when θ=90° static light scattering detection is used, instead of a full angular extrapolation via MALS.  
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Characterizing the Thermal and Chemical Stability of a mAb

In these experiments, ARGEN was used to characterize the thermal and chemical stability of a monoclonal antibody and subsequently establish quantitative and qualitative properties such as pH and temperature dependence on aggregation kinetics. Additionally, SEC elution profiles were superimposed onto Mw/Mo output, providing a robust comparison and identification of the stability landscape for the mAb....
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Biopolymer Characterization & Polymer Degradation

Understanding the thermal, chemical and mechanical stability and physical properties of polymers is essential for development success. The case studies below outline the experimental methodologies and data analysis using ARGEN™ to monitor polymer degradation and to characterize molecular weight as well as the effects of temperature, shear stress and solution conditions on the stability of...
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Introduction to ACOMP

ACOMP: The Automated System that allows Continuous Realtime Monitoring of Polymerization Reactions
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