Characterizing colloidal stability is central to developing safe and efficacious protein-based therapeutics. To be viable, the target biotherapeutic must remain stable during production, storage, and patient delivery. The most insightful and successful techniques for monitoring and characterizing colloidal stability involve in-situ and real time analysis under modelled stress conditions. This permits the investigation of solution...Read More
Colloidal stability is determined by the balance of repulsive and attractive intermolecular interactions between protein molecules, like a monoclonal antibody, to conserve the native folded state. Simply stated, the propensity for aggregation is reduced by less intermolecular interaction. Therefore, determination of the second virial coefficient (B22) is a valuable screening tool to predict aggregation propensity....Read More
