Application Notes

ACOMP Digital Booklet

Real-time analytics is a huge focus area for us here at Fluence Analytics because we understand that these insights can truly transform a business in several areas. Many of our customers seek to reduce operational expenses because this allows them to gain greater market share by offering more competitive prices. Some of our customers are...
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Monitoring EPDM Rubber

Determining Correlations in EPDM Rubber between Compositional Properties, Rheological Properties, and Detectable Trends via ACOMP Authors: Michael F. Drenski, Dr. Matthew Crosley, Fluence Analytics David G. Ward (Lion Elastomers), Josh Vaughn (formerly with Lion Elastomers)
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Rapid Determination of Mw for a Monoclonal Antibody

Colloidal stability is determined by the balance of repulsive and attractive intermolecular interactions between protein molecules, like a monoclonal antibody, to conserve the native folded state. Simply stated, the propensity for aggregation is reduced by less intermolecular interaction. Therefore, determination of the second virial coefficient (B22) is a valuable screening tool to predict aggregation propensity....
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Kinetic Analysis of Protein Stability & Oligomeric State Transitions of Human Insulin

These experiments demonstrate the utility of ARGEN™ to define oligomeric states and transitions of Human Insulin under thermal stress. Time to dimerization and time to tetramerization measurements permitted the characterization of a stable dimer species, as well as insights into the mechanisms and kinetics of higher order oligomer formation. Whereas, SEC allows the characterization of...
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Comparing Protein Stability

Biopharmaceutical companies isolate many types of proteins for use in experimental and therapeutic medicines. Unfortunately, when removed from their native environments, proteins become less stable. Unstable proteins are more prone to degradation from the primary stress mechanisms: mechanical and thermal (from manufacturing, storage and transport) and biological (from drug delivery). The challenge for biopharmaceutical companies...
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