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ARGEN

Kinetic Analysis of Protein Stability & Oligomeric State Transitions of Human Insulin

These experiments demonstrate the utility of ARGEN™ to define oligomeric states and transitions of Human Insulin under thermal stress. Time to dimerization and time to tetramerization measurements permitted the characterization of a stable dimer species, as well as insights into the mechanisms and kinetics of higher order oligomer formation. Whereas, SEC allows the characterization of...
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Introduction to ARGEN

Rapid Analysis of Protein Formulation Stability ARGEN, by Fluence Analytics, adds another powerful tool to the protein scientist’s arsenal. ARGEN is a light scattering instrument with 16 independent sample cells that can test for protein aggregation while stressing samples under multiple conditions including chemical, mechanical and thermal…all in real time and accelerating protein formulation stability!...
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Automated & Rapid Way to Assess Quality & Stability of Biologics

Determine the Stability of Biologics This peer review article from American Pharmaceutical Review describes new tools for determining the stability of biologics, including ARGEN by Fluence Analytics, that not only have low sample requirements but also generate precise and reproducible data to effectively implement an advanced design of experiments approach. This article uses a real case...
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Fluence Analytics to exhibit and present new developments in use of light scattering to determine aggregation rates at PepTalk 2018

PepTalk, one of the largest annual conferences for protein researchers in the world, will take place from January 8-12, 2018 at the Hilton San Diego Bayfront. Fluence Analytics is attending the 17th annual conference and will showcase ARGEN at exhibition booth number 315. The booth will feature an ARGEN system with software demos, and members of...
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Characterizing the Thermal and Chemical Stability of a mAb

In these experiments, ARGEN was used to characterize the thermal and chemical stability of a monoclonal antibody and subsequently establish quantitative and qualitative properties such as pH and temperature dependence on aggregation kinetics. Additionally, SEC elution profiles were superimposed onto Mw/Mo output, providing a robust comparison and identification of the stability landscape for the mAb....
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Biopolymer Characterization & Polymer Degradation

Understanding the thermal, chemical and mechanical stability and physical properties of polymers is essential for development success. The case studies below outline the experimental methodologies and data analysis using ARGEN™ to monitor polymer degradation and to characterize molecular weight as well as the effects of temperature, shear stress and solution conditions on the stability of...
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ARGEN Brochure

ARGEN Brochure: Protein Stability Monitoring
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Fluence Analytics Announces ARGEN Product Launch

New Instrument Continuously Analyzes Protein and Natural Polymer Aggregation (New Orleans, LA, U.S.) ‒ Fluence Analytics, a manufacturer of realtime, industrial and laboratory monitoring systems, today announced the launch of ARGEN, a patented protein and polymer stability monitoring product. By utilizing continuous light scattering measurements, ARGEN yields a unique information stream which reduces discovery and...
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Fluence Analytics Webinar – Rapid Analysis of Protein Formulation Stability

Protein aggregation has presented biopharmaceutical scientists with constant difficulties during formulation development. Historically, batch-based methods such as SEC, HPLC and other aggregation detectors offer incomplete solutions because they do not provide scientists with realtime kinetic data on protein stability nor insight into the mechanisms of protein aggregation. ARGEN, an instrument by Fluence Analytics, adds a powerful tool to the protein scientist’s arsenal. ARGEN is a light scattering instrument...
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Fluence Analytics CTO to Show ARGEN’s Capabilities at Polymer Testing & Analysis Conference in Pittsburgh

Michael Drenski, CTO of Fluence Analytics, is attending  AMI’s first Polymer Testing & Analysis 2017 Conference at the Pittsburgh Marriott City Center, and he will present data from using ARGEN to monitor and characterize polymer degradation of polystyrene. Michael’s talk is scheduled for Session 5 on Wednesday, September 20 at 9:10 a.m. ARGEN is a light scattering instrument...
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