The data presented in this paper is generated from SLS and DLS experiments that monitored the solution behavior of rAAV capsids with and without DNA. The comparison and superimposition of SLS and DLS scattering profiles provides insights into the differential colloidal stability of the full and empty species, as well as a dynamic quantification of...Read More
This dynamic webinar offers insights into characterizing the stability of an engineered adeno-associated virus (AAV) serotype under moderate thermal stress and physiological solution conditions using light scattering measurements. This webinar highlights experiments that investigated and characterized the effects of thermally-induced perturbations on DNA ejection from a proprietary AAV vector. The experiments were conducted at three...Read More
The academic research partner of Yokogawa Fluence Analytics, Tulane PolyRMC, partnered with Spark Therapeutics on a new peer-reviewed article in Biomacromolecules that highlights the degradation of adeno-associated virus (AAV) under moderate thermal stress (30−53°C) and in physiological solution (pH7.2, 180 mM NaCl). Read More
