Characterizing colloidal stability is central to developing safe and efficacious protein-based therapeutics. To be viable, the target biotherapeutic must remain stable during production, storage, and patient delivery. The most insightful and successful techniques for monitoring and characterizing colloidal stability involve in-situ and real time analysis under modelled stress conditions. This permits the investigation of solution...Read More
This article provides a high-level comparison of light scattering techniques, including similarities and differences between them in biopharma applications.Read More
Scientists involved in biopharmaceutical research face several key challenges during the development of therapeutic proteins, peptides and RNA. This article explores key challenges and innovations in biopharmaceutical formulation development that help scientists overcome those challenges.Read More
ARGEN is a robust platform that can expand biopolymer formulation development efforts via novel data sets. The precision instrument addresses key challenges in biopolymer research by offering in-situ, real-time stability monitoring, manufacturing stress modelling, shelf-life determination, and rapid parallel analysis, leading to more efficient and effective formulation development.Read More
The ARGEN eBook discusses the key indicators of biopolymer instability, the importance of accelerating development times, and how ARGEN expedites the development of stable biopolymers.Read More
The ARGEN Digital Booklet provides insight into various applications utilizing ARGEN’s patented simultaneous multiple sample light scattering (SMSLS) technology to accelerate and optimize the development of novel biotherapeutics. Biopharmaceutical companies are experiencing greater demand to develop novel biologic therapeutics in less time, and this requires a paradigm shift in the way teams approach formulation development...Read More
Determine the Stability of Biologics This peer review article from American Pharmaceutical Review describes new tools for determining the stability of biologics, including ARGEN by Fluence Analytics, that not only have low sample requirements but also generate precise and reproducible data to effectively implement an advanced design of experiments approach. This article uses a real case...Read More
Understanding the thermal, chemical and mechanical stability and physical properties of polymers is essential for development success. The case studies below outline the experimental methodologies and data analysis using ARGEN™ to monitor polymer degradation and to characterize molecular weight as well as the effects of temperature, shear stress and solution conditions on the stability of...Read More
Biopharmaceutical companies isolate many types of proteins for use in experimental and therapeutic medicines. Unfortunately, when removed from their native environments, proteins become less stable. Unstable proteins are more prone to degradation from the primary stress mechanisms: mechanical and thermal (from manufacturing, storage and transport) and biological (from drug delivery). The challenge for biopharmaceutical companies...Read More
