This dynamic webinar will offer insights into characterizing the stability of an engineered adeno-associated virus (AAV) serotype under moderate thermal stress and physiological solution conditions using light scattering measurements. The webinar will highlight the experiments that investigated and characterized the effects of thermally-induced perturbations at three temperature setpoints on DNA ejection from a proprietary AAV...Read More
In the rapidly evolving world of biopharmaceutical research, the search to optimize formulation development efforts and understand peptide stability has taken center stage. With a myriad of applications ranging from the treatment of diseases to novel delivery systems, the potential of peptides is vast. Read More
In the high-stakes realm of biopharmaceutical research and development, understanding antibody stability is very important. Antibody stability is a multi-faceted concern that includes aspects of aggregation, degradation, and conformational integrity. Each of these potential problems can negatively impact antibody stability and the performance and manufacturability of biotherapeutics.Read More
In the realm of biopharmaceuticals, custom peptide and oligonucleotide development has opened new horizons for targeted therapeutic interventions. However, the success of peptide and oligonucleotide development hinges significantly on a comprehensive understanding of their stability. However, biopharma teams using ARGEN can access real-time stability insights as they develop peptide, oligonucleotide, and protein-based therapeutics. Read More
Recent research on stress factors in monoclonal antibody development underscores the critical need for robust control strategies in monoclonal antibody drug substance production, focusing on the risks posed by various stress conditions during manufacturing. These stressors can lead to protein modifications, impacting both patient safety and product quality. ARGEN, by Yokogawa Fluence Analytics, is a...Read More
Characterizing colloidal stability is central to developing safe and efficacious protein-based therapeutics. To be viable, the target biotherapeutic must remain stable during production, storage, and patient delivery. The most insightful and successful techniques for monitoring and characterizing colloidal stability involve in-situ and real time analysis under modelled stress conditions. This permits the investigation of solution...Read More
This article provides a high-level comparison of light scattering techniques, including similarities and differences between them in biopharma applications.Read More
Scientists involved in biopharmaceutical research face several key challenges during the development of therapeutic proteins, peptides and RNA. This article explores key challenges and innovations in biopharmaceutical formulation development that help scientists overcome those challenges.Read More
ARGEN is a robust platform that can expand biopolymer formulation development efforts via novel data sets. The precision instrument addresses key challenges in biopolymer research by offering in-situ, real-time stability monitoring, manufacturing stress modelling, shelf-life determination, and rapid parallel analysis, leading to more efficient and effective formulation development.Read More
