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technical note

ACOMP Feedback Controller for Polymer Molecular Weight

In this technical note we will demonstrate the use of active feedback control with Lab ACOMP to directly control polymer molecular weight by adjusting the monomer feed into the reactor. By integrating ACOMP with a feedback controller, molecular weight is directly controlled, something previously not possible in polymerizations.
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Polymer Quality Control with ACOMP

Using ACOMP in an industrial environment allows for improved polymer quality control of production processes and material properties. With the benefit of an online, real-time analysis provided by ACOMP, plant operators can take corrective actions to change QC parameters or even halt the reaction if the product properties are deviating too much.
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ACOMP Analytics during Polyacrylamide Polymerizations

ACOMP provides a real-time, online analysis of polymerization reactions. This technical note describes how ACOMP can track the properties of polyacrylamide produced with different initiator types and concentrations. This note compares the effects of initiator type and concentration in the synthesis of polyacrylamide, a specialty polymer with many industrial applications.
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Characterizing Polyurethane Polymerizations with ACOMP

This technical note demonstrates the use of ACOMP to monitor two types of polyurethane polymerizations, the industry standard and a novel type using a non-toxic isocyanate monomer. The ACOMP system can monitor in real time the intrinsic viscosity and molecular weight for the stepwise polymerization reaction that occurs.
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Real-time Monitoring of Solution Styrene Butadiene Rubber

ACOMP was used to continuously measure the anionic polymerization of solution styrene butadiene rubber. ACOMP successfully tracked conversion, along with weight-average molecular weight (Mw), and low and high shear reduced viscosities (RV), including during the coupling reaction.
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Monitoring Pressure Sensitive Adhesives

This technical note describes the use of ACOMP to monitor polymerization kinetics, intrinsic viscosity and Mw in a very common system for producing pressure sensitive adhesives, which uses the acrylic comonomers acrylic acid (AA) and 2-ethylhexyl acrylate (2EHA).
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Assessing Stirring Stress and Other Impacts of Bioprocessing

The successful development of biotherapeutics requires an in-depth understanding of the impacts associated with mechanical and physical stress. Instability and subsequent aggregation can render them biologically inactive or even induce an immunological response in patients. Stirring stress is one of the most notable factors which disrupts native biopolymer structure and promotes aggregation. However, contact stirring...
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Using 90° SLS to Determine Mw

On the limits of 90° static light scattering for determining weight average molar mass Mw A discussion with Chief Science Officer, Dr. Wayne Reed Technical Note 003 assesses the fractional error in Mw that results when θ=90° detection is used, instead of a full angular extrapolation via MALS.  
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Monitoring the Polymerization of Polymethylmethacrylate

The polymerization of PMMA can occur through various methods, including in liquid-phase solution, in a bulk extrusion process, and via casting. ACOMP is an online, smart manufacturing system that continuously monitors polymer properties in real time. This technical note illustrates how ACOMP can successfully monitor and characterize the solution polymerization of PMMA in the presence...
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Characterizing the Thermal & Chemical Stability of a mAb

In these experiments, ARGEN was used to characterize the thermal and chemical stability of a monoclonal antibody and subsequently establish quantitative and qualitative properties such as pH and temperature dependence on aggregation kinetics. Additionally, SEC elution profiles were superimposed onto Mw/Mo output, providing a robust comparison and identification of the stability landscape for the mAb....
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